Cisplatin hearing loss thesis

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August undefined, 2024

WebJan 1, 2024 · Atorvastatin use significantly reduces the odds of a clinically meaningful cisplatin-induced hearing loss. An analysis of the incidence of a CTCAE-defined hearing loss due to cisplatin therapy in the full cohort and key subgroups is shown. For the full cohort and the subject subgroups, the difference in the incidence (% of ears) and 95% CI … WebJul 13, 2024 · “Around 60% to 80% of kids who get cisplatin have significant hearing loss,” Dr. Neuwelt explained. The impact of that hearing loss can be profound, he continued, including greatly increasing the risk …

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WebJan 1, 2024 · Cisplatin-induced hearing loss is permanent, and there are currently no FDA-approved therapies to reduce or prevent cisplatin ototoxicity. Here we explore the … WebNov 21, 2024 · Cisplatin chemotherapy causes permanent hearing loss in 40-80% of treated patients. It is unclear whether the cochlea has unique sensitivity to cisplatin or is exposed to higher levels of the drug. Here we use inductively coupled plasma mass spectrometry (ICP-MS) to examine cisplatin pharmacokinetic … how long before a tooth nerve dies

Atorvastatin is associated with reduced cisplatin-induced hearing …

Web• Investigating molecular mechanisms underlying cisplatin and noise-induced hearing loss • Determining the role of transplatin as an … Web20 hours ago · The drug, which is Fennec's sole product, is intended to prevent hearing loss in pediatric cancer patients treated with cisplatin chemotherapy. WebAug 31, 2016 · Cisplatin is an effective drug used in the treatment of many cancers, yet its ototoxic potential places cancer patients, exposed to this drug, at risk of hearing loss, thus negatively impacting further on a patient’s quality of life. It is paramount for health care practitioners managing such patients to be aware of cisplatin’s ototoxic … how long before a statin reduces cholesterol

High-frequency monitoring for early detection of cisplatin ... - PubMed

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WebMar 24, 2014 · Detailed Description: The study is a dose-finding study of N-acetylcysteine (NAC) to protect hearing in children receiving cisplatin for the treatment of their cancer. NAC also has potential to protect the kidneys from cisplatin toxicity. The study uses a 3+3 dose-escalation scheme to determine the dose of NAC necessary to achieve serum … WebThe impact of hearing loss can be devastating and is often associated with tinnitus, imbalance, or a debilitating sensitivity to sound. Cisplatin is commonly used with curative intent. As such, protecting the patient’s quality of life after cisplatin chemotherapy should be of high interest to both physicians and patients. how long before atenolol takes effectWebFeb 11, 2024 · Cisplatin is a highly effective chemotherapeutic drug used against a wide range of childhood and adult cancers, but cisplatin … how long before b12 works

"WebMar 29, 2024 · This hearing disorder results from temporary or permanent inner ear dysfunction, typically causing bilateral high-frequency sensorineural hearing loss that progresses to lower frequencies with continued exposure. 3 The risk of permanent bilateral sensorineural hearing loss and tinnitus can occur both during treatment and long-term … " - Cisplatin hearing loss thesis

Cisplatin hearing loss thesis

High-dose cisplatin treatment: hearing loss and plasma

WebBackground: Sensorineural hearing loss is a well-known side effect of cisplatin (CDDP). There is limited research on the effect of dosing, infusion times, and schedules of cisplatin administration and their impact on hearing loss. Methods: A retrospective review of 993 pediatric patients’ medical and audiological WebNoise-induced hearing loss (NIHL) is a complex disease which might be caused by interactions between environmental and genetic factors. Noise is the best-known and one of the most studied environmental factors causing hearing loss.

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WebSep 4, 2024 · Scientists have found out why Cisplatin causes hearing loss. Cisplatin is a powerful drug used in some chemotherapy treatments to treat many forms of cancer. … WebJun 21, 2024 · Hearing loss of grade 1 or higher occurred in 18 of 55 children (33%) in the cisplatin–sodium thiosulfate group, as compared with 29 of 46 (63%) in the cisplatin-alone group, indicating a 48% ...

WebThe incidence of ototoxicity induced by cisplatin ranges from 20% to 70%, and it usually manifests as a progressive, bilateral and irreversible hearing loss. Although the etiology … WebCisplatin is one of the most effective chemotherapy agents, used in just under half of pediatric cancer cases. Permanent hearing loss is a common side effect of this …

WebMar 26, 2024 · The severity of cisplatin-related ototoxicity is associated with age and the cumulative dose received: the younger the child and the higher the total dose, the more severe the hearing loss may be. The spectrum of hearing loss varies from mild to moderate high tone hearing loss, to profound loss across the hearing range and … WebApr 26, 2024 · 1 In a recent study, most patients (388 of 488, 80%) had a hearing loss of at least 20 dB and 40% suffered from tinnitus. 2 Sixty-three to 77% of children 3 4 suffer permanent sensorineural hearing loss from cisplatin chemotherapy. Cisplatin primarily affects the high frequencies in both ears and is permanent.

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how long before b12 takes effectWebHearing loss induced by cisplatin or aminoglycosides is generally bilateral and begins at high frequencies, extend-ing to lower frequencies with prolonged treatment. … how long before azithromycin takes effectWebCISPLATIN-INDUCED OTOTOXICITY: THE CURRENT STATE OF OTOTOXICITY MONITORING IN NEW ZEALAND _____ A thesis submitted in partial fulfilment of the … how long before autopsy reports are completehttp://etds.lib.ncku.edu.tw/etdservice/detail?n=20&etdun3=U0026-0808201316053000&etdun4=U0026-2308201215132500&etdun7=U0026-2607201113092800&etdun9=U0026-0108201016204100&etdun10=U0026-2706201001360500&etdun11=U0026-2601201019334400&etdun12=U0026-2408201016131400&etdun18=U0026-0812200911435655&etdun19=U0026-0812200911293383&etdun20=U0026-0812200911134013 how long before a tourniquet causes damageWebFeb 12, 2024 · More information: Diana J Moke et al. Prevalence and risk factors for cisplatin-induced hearing loss in children, adolescents, and young adults: a multi-institutional North American cohort study ... how long before azithromycin worksWebMay 19, 2024 · Cisplatin may cause hearing loss as a side effect. In the average-risk medulloblastoma patients, this trial tests whether the addition of sodium thiosulfate (STS) to standard of care chemotherapy and radiation therapy reduces hearing loss. Previous studies with STS have shown that it may help reduce or prevent hearing loss caused by … how long before b12 injections take effectWebNov 29, 2024 · Effects of sodium thiosulfate versus observation on development of cisplatin-induced hearing loss in children with cancer (ACCL0431): A multicentre, randomised, controlled, open-label, phase 3 ... how long before azithromycin starts working