WebNX_P10909 - CLU - Clusterin - Function. Functions as extracellular chaperone that prevents aggregation of non native proteins (PubMed:11123922, PubMed:19535339). Prevents stress-induced aggregation of blood plasma proteins (PubMed:11123922, PubMed:12176985, PubMed:17260971, PubMed:19996109). Inhibits formation of … WebCLUSTERIN alpha chain: SMART accession number: SM00035 Description: - Interpro abstract : Clusterin is a vertebrate glycoprotein [ (PUBMED:1585460) ], the exact function of which is not yet clear. Clusterin expression is complex, appearing as different forms in different cell compartments. One set of proteins is directed for secretion, and ...

Clusterin alpha Antibody [130-10439] - raybiotech.com

WebMar 26, 2013 · Transcript levels of select RAGs encoding cell adhesion proteins were compared between two human endometrial epithelial cell lines; RL95-2 and HEC-1-A by quantitative real time polymerase chain reaction (q-RT-PCR). Webα 2 M and misfolded proteins are internalized into cells for lysosomal degradation. We recently discovered that clusterin mediates the lysosomal degradation of extracellular abnormal proteins 10.To determine whether another extracellular chaperone, α 2 M, also participates in the lysosomal degradation pathway, we produced a recombinant protein … remax realty winchester tn

CLU antibody Anti-CLU stjohnslabs

WebOct 27, 2016 · Background. Amyloidosis is a rare but devastating condition caused by deposition of misfolded proteins as aggregates in the extracellular tissues of the body, leading to impairment of organ function [].Many, but not a limitless number of proteins can cause amyloidosis [].The most common are immunoglobulin light chain (AL), … WebThe expression of clusterin, p65, Bax, Bcl-xL, IL-1β, and TNF-α protein and mRNA in heart tissue and H9C2 cells was detected by western blot, reverse transcription-polymerase chain reaction (RT-PCR), and quantitative RT-PCR assays; IL-1β and TNF-α protein was detected by enzyme-linked immunosorbent assays; NF-kB activity was detected by an ... WebSpecificity of this antibody: Clusterin alpha chain. Target Information Isoform 1 of Clusterin prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. remax red deer alberta asha