Tim4 gene name

Author: kmkr

August undefined, 2024

WebTargeted disruption of the Tim4 gene The Tim4-targeted mice were generated as custom order by Unitech (Kashiwa, Chiba, Japan). In brief, the Tim4 chromosomal gene was isolated from BAC clones of C57BL/6 mice, and its exon 1 and most of exon 2 were replaced by a coding sequence for Venus and neo gene (Fig. 1). Web25 set 2024 · Previous studies demonstrated that TIM1 was a susceptibility gene for asthma and allergy, which was preferentially expressed on activated Th2 cells; by contract, TIM4 is mainly expressed on antigen-presenting cells (APCs) ( 8 ).

Vitamin D regulates immunoglobulin mucin domain molecule …

WebT-cell immunoglobulin and mucin domain-containing protein 4 (UniProt Q6U7R4; also known as SMUCKLER, Spleen, mucin-containing, knockout of lymphotoxin protein, T-cell immunoglobulin mucin receptor 4, T-cell membrane protein 4, TIM-4, TIMD-4) is encoded by the Timd4 (also known as Tim4) gene (Gene ID 276891) in murine species. T-cell immunoglobulin and mucin domain containing 4 (TIMD-4) also known as T-cell membrane protein 4 (TIM-4) is a protein in humans that is encoded by the TIMD4 gene. TIM-4 genes are in mouse present on chromosome 11B1.1 and in humans on chromosome 5q33.2. TIM-4 contains IgV domain with integrin-binding site as well as a unique metal-ion-dependent ligand binding site for phosphatidyl… mountain lake shower curtain

SMUCKLER/TIM4 is a distinct member of TIM family expressed by …

Web22 gen 2024 · Tim-4 functions as a scavenger receptor for phagocytosis of exogenous particles. A scaffold for signaling of Tim-4-mediated efferocytosis is formed by … Web12 lug 2024 · Cavity-resident macrophages express high levels of Tim-4, a receptor for phosphatidylserine (PS), and this is associated with reduced numbers of CD8+T cells with tumor-reactive features in pleural effusions and peritoneal ascites from patients with cancer. Web15 nov 2007 · The antigen recognized by the antibody was identified by expression cloning as a type I transmembrane protein called Tim4 (T-cell immunoglobulin- and mucin … mountain lakes insurance buckhannon wv

Vitamin D regulates immunoglobulin mucin domain molecule …

276891 - Gene ResultTimd4 T cell immunoglobulin and mucin …

WebAlias : TIMD4, TIM4, SMUCKLER T-cell immunoglobulin and mucin domain containing 4. T-cell immunoglobulin mucin receptor 4. T-cell membrane protein 4. Back to the top Specifications Human TIM4 isoform 1 (pUNO1-hTIM4a) Genbank : JX049980.1 ORF size : 1137 bp Subclone : BspLU11I - NheI Back to the top pUNO1 Contents 20 µg of … WebNX_Q96H15 - TIMD4 - T-cell immunoglobulin and mucin domain-containing protein 4 - Computed references. Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Involved in regulating T-cell proliferation and lymphotoxin signaling. Ligand for HAVCR1/TIMD1 (By similarity). hearing device for cell phoneWebPROTEIN SUMMARY SECTION OVERVIEW RNA DATA ANTIBODY DATA. TIMD4 INFORMATION. Proteini. Full gene name according to HGNC. T cell immunoglobulin … hearing device for telephone

"Web22 feb 2016 · TIM4 (T cell immunoglobulin mucin domain molecule-4) plays a critical role in the initiation of skewed T helper (Th) 2 polarization. The factors regulating TIM4 expression are unclear. This study ... " - Tim4 gene name

Tim4 gene name

Human TIM-4 ELISA Kit - Invitrogen - Thermo Fisher Scientific

WebBelongs to the immunoglobulin superfamily. TIM family. Tim4/TIMD4 protein name Recommended name T-cell immunoglobulin and mucin domain-containing protein 4 … WebT cell immunoglobulin and mucin domains containing protein 4 (TIM4, TIMD4) is a phosphatidylserine receptor that mediates phagocytosis of apoptotic cells. It is involved in the regulation of T helper cells (Th1 and Th2) immune responses. TIM4 binds apoptotic cells by recognizing phosphatidylserine through its immunoglobulin domain.

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WebTim-4 is a transmembrane protein known as T cell immunoglobulin and mucin domain containing protein-4. It is expressed on antigen-presenting cells and not on T cells. Tim-4 binds to Tim-1 to promote T cell proliferation by enhancing cell …

WebTIM-4 is also known as Spleen, mucin-containing, knockout of lymphotoxin protein (SMUCKLER). TIM-4 is a single-pass type I membrane transmembrane glycoprotein … WebThis Anti-TIM4/TIMD-4 Antibody, clone Kat5-18 is validated for use in Flow Cytometry and Neutralizing for the detection of ... TIMD-4, Smuckler) is encoded by the Timd4 (also known as B430010N18Rik, Tim4) gene (Gene ID 276891) in murine species. Phagocytes, including macrophages, target apoptotic cells for engulfment by recognizing their ...

WebTIM-4, which is preferentially expressed on macrophages and dendritic cells, is the natural ligand of TIM-1, and this binding leads to T-cell expansion and cytokine production. … Web21 feb 2006 · Status. UniProtKB unreviewed (TrEMBL) Organism. Homo sapiens (Human) Amino acids. 262. Protein existence. Evidence at transcript level. Annotation score.

Web9 feb 2024 · Identification of Tim4 as a receptor for carbon nanomaterials. To identify phagocyte receptors for MWCNTs, we reconstituted NIH 3T3 cells, a mouse fibroblast …

Web21 mar 2024 · TIMD4 (T Cell Immunoglobulin And Mucin Domain Containing 4) is a Protein Coding gene. Diseases associated with TIMD4 include Histiocytic Sarcoma and Langerhans Cell Sarcoma . Among its … hearing device for elderlyWebBackground: Dendritic cell (DC)-derived immunoglobulin domain molecule (TIM)4 plays a critical role in the initiation of T helper (Th)2 polarization. Vitamin D (VitD) involves the regulation of a number of immune responses. Objectives: This study tests a hypothesis that VitD regulates TIM4 expression in DCs. Methods: Peripheral blood samples were … hearing device for huntingWebTIM-4 (T cell; immunoglobulin; mucin-4), also known as SMUCKLER, is a 60 kDa member of the TIM family of immune regulating proteins. TIMs are type I transmembrane proteins … mountain lakes medical center ceoWeb26 set 2024 · Gene silencing. The TIM4 gene in splenic DCs and the TIM1 gene in CD4 T cells were knocked down by RNA interfer-ence with reagent kits [Lipofectamine™ 3000 Transfection Reagent (L3000015); Invitrogen, Shanghai, China] following the manufacturer's instructions. The effect of gene silenc ing was assessed by western blotting. Flow … hearing device for phoneWebTIM-4 (T cell; immunoglobulin; mucin-4), also known as SMUCKLER, is a 60 kDa member of the TIM family of immune regulating proteins. TIMs are type I transmembrane proteins … mountain lakes library websiteWeb20 giu 2012 · Establishment of Tim4-deficient mice.(A) Targeting of the Tim4 gene. Schematic representation of the wild-type and mutant loci of the Tim4 gene and the targeting vector. Exons are represented by closed boxes. The targeting vector carries the neomycin resistance gene (neo) and the gene encoding the Diphtheria toxin A fragment … mountain lakes lodge grand lake coWeb26 feb 2024 · TIM-4 gene polymorphisms are associated with asthma in a Chinese Han population. Overexpression of TIM-4 on antigen- presenting cells in transgenic mice … hearing devices for churches